Pathophysiology of benign prostate enlargement and lower urinary tract symptoms: Current concepts
نویسندگان
چکیده
Lower urinary tract symptoms (LUTS) are highly prevalent in the aging population, particularly in men. Historically, prostate enlargement was thought to be responsible for most cases of male LUTS. Several risk factors for the development of benign prostate enlargement/hyperplasia (BPE/BPH) have been identified, including age, genetics, hormones, growth factors, inflammation, and lifestyle factors. However, as our knowledge continues to evolve, male LUTS are no longer managed entirely in a prostate-centric fashion. In this article, we review current concepts in the epidemiology, etiology, and pathophysiology of BPE/BPH and male LUTS.
منابع مشابه
Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis.
OBJECTIVE To summarise and meta-analyse current literature on metabolic syndrome (MetS) and benign prostatic enlargement (BPE), focusing on all the components of MetS and their relationship with prostate volume, transitional zone volume, prostate-specific antigen and urinary symptoms, as evidence suggests an association between MetS and lower urinary tract symptoms (LUTS) due to BPE. METHODS ...
متن کاملSilodosin 8 mg improves benign prostatic obstruction in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement: results from an explorative clinical study
BACKGROUND To preliminary investigate the effects of silodosin 8 mg once daily on obstruction urodynamic parameters and subjective symptoms in Caucasian patients with lower urinary tract symptoms suggestive of benign prostatic enlargement. METHODS We performed a single-center, open-label, single-arm, post-marketing interventional clinical trial. Inclusion criteria were: Caucasian subjects age...
متن کاملFinasteride in the treatment of patients with benign prostatic hyperplasia: a review
Benign prostatic hyperplasia (BPH) is a complex and progressive disease common in aging men. While associated with bothersome lower urinary tract symptoms, it may also result in additional serious complications such as refractory hematuria, acute urinary retention, and BPH-related surgery. Medical therapy has been offered as an approach to halt this progression and perhaps reverse the pathophys...
متن کاملLower urinary tract symptoms revisited.
In recent years, there has been an increased awareness of the importance of considering lower urinary tract symptoms (LUTS) as a global term. Under this umbrella term, disorders of bladder function can be most effectively considered as failure to store or failure to empty. We now clearly recognise the misconceptions inherent in the assumptions that all LUTS in men are caused by benign prostatic...
متن کاملA Focus on Benign Prostatic Hyperplasia and Prostate Cancer Prevention
STATEMENT OF NEED Within the demographic context of an aging population, urologic health has assumed an increasingly prominent position in the overall health status of the American male. Prostate disease, in particular, is one of the most common health issues in men. Most men 50 years of age or older have prostate enlargement (benign prostatic hyperplasia [BPH] and/or lower urinary tract sympto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 29 شماره
صفحات -
تاریخ انتشار 2017